The 4 Types of Rejuran: Healer, HB Plus, I and S Compared

Dr. Designer Clinic Yeongdeungpo · Updated 2026-09 · Korean original ↗

"What is the difference between Healer and HB Plus?" "Do I need Rejuran I for the eyes?" The four products share a name but differ in concentration, texture and the area they suit. Here is how we explain them, including pain and how long the bumps last.

What they have in common: all four use polynucleotides (PN) derived from salmon DNA as the core ingredient. PN supports the skin's own repair process. Each product changes the concentration, viscosity and added ingredients to fit a different area.

1. Rejuran Healer: the original

Rejuran Healer is the basic formula, with PN as its main ingredient. It can be injected evenly across the whole face and is the reference product when the goal is overall skin quality: texture, elasticity, inner dryness and fine lines.

Because it is viscous, injection stings more than the other types, and the small raised bumps at injection points can last 3–5 days. Plan your schedule with that in mind.

2. Rejuran HB Plus: less pain, more hydration

HB Plus was developed to reduce the discomfort of Healer. It combines PN with hyaluronic acid and lidocaine, so injection is usually less uncomfortable and there is an added hydration and glow effect. Its composition differs from Healer; see each product's official specifications.

It suits patients who want repair plus a hydrated, dewy finish, and those who have hesitated because of pain. With its lower viscosity the bumps usually settle in 1–3 days.

3. Rejuran I: for the thin eye area

Rejuran I is a low-viscosity formula designed for the skin around the eyes, the thinnest on the face. A thick product there causes bruising and long-lasting bumps, so I has its viscosity adjusted for the eye area. It is chosen for crow's feet, dark circles and dullness under the eyes, and loss of elasticity at the eye corners.

4. Rejuran S: for scars

Rejuran S is the thickest formula, made for depressed acne scars and other indented marks. Its firmer texture stays where it is placed, so the doctor can target scar tissue precisely. It is usually combined with a scar treatment such as fractional laser for the best result.

At a glance

Who we do not recommend it for

• Pregnant or breastfeeding patients, and anyone with a fish allergy.
• Active infection or inflamed acne in the area.
• Patients who cannot accept visible bumps for a few days.

On the day

• No makeup if possible; numbing cream is applied for 20–30 minutes.
• Avoid alcohol the night before.
• Bring a list of any medication and supplements.

Frequently asked questions

Which one should I start with?

For overall skin quality, Healer if you tolerate the sting, HB Plus if comfort matters more. For scars, S. For the eyes, I.

Is the difference between Healer and HB Plus large?

Healer is the basic PN formula; HB Plus adds hydration and lidocaine. Over a course of three sessions both can improve texture, and HB Plus tends to give a more noticeable glow. Results vary from person to person.

Can I do the eyes and the face together?

Yes. Rejuran I for the eyes and Healer or HB Plus for the face are commonly combined in one session, and there is a full-face package.

How long do the bumps last?

1–3 days for HB Plus and I, 3–5 days for Healer, 2–4 days for S. Cool compresses help.

What is best for acne scars?

Rejuran S, often combined with fractional laser or subcision depending on the scar type.

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This guide is general information written by Dr. Designer Clinic Yeongdeungpo and is not a substitute for a consultation. Results, downtime and suitability vary by individual and are decided after an in-person examination by the doctor.